One simple, practical aspect of maturity effects on NDF digestibility in forages is related to changes in leaf-to-stem ratio. The NDF in legume or grass leaves is significantly more digestible than NDF in stem tissue. As forage matures, leaf-to-stem ratio declines (more stem, fewer leaves) and as a result NDF digestibility declines because a greater portion of the total NDF is NDF associated with stem tissue. Corn silage is unique in defining maturity effects on NDF digestibility because leaf-to-stem ratio is not greatly altered across normal harvest maturity stages. It is actually common to observe a decline in total NDF content in corn silage as the corn plant matures. This is because the corn ear is filling with grain, which dilutes the total forage NDF content. Despite this illusionary maturity effect, the NDF digestibility of the corn plant still declines with advancing maturity (Figure 3) mainly due to advancing lignification of cell walls (NDF).
The immune response modifiers, imiquimod and resiquimod, are TLR7 agonists that induce type I interferon in numerous species, including humans. Recently, it was shown that plasmacytoid dendritic cells (pDC) are the primary interferon-producing cells in the blood in response to viral infections. Here, we characterize the activation of human pDC with the TLR7 agonists imiquimod and resiquimod. Results indicate that imiquimod and resiquimod induce IFN-alpha and IFN-omega from purified pDC, and pDC are the principle IFN-producing cells in the blood. Resiquimod-stimulated pDC also produce a number of other cytokines including TNF-alpha and IP-10. Resiquimod enhances co-stimulatory marker expression, CCR7 expression, and pDC viability. Resiquimod was compared throughout the study to the pDC survival factors, IL-3 and IFN-alpha; resiquimod more effectively matures pDC than either IL-3 or IFN-alpha alone. These results demonstrate that imidazoquinoline molecules directly induce pDC maturation as determined by cytokine induction, CCR7 and co-stimulatory marker expression and prolonging viability.
Marie Valentine! ! If your balls are ready to give three cheers for an all-American slut superstar, they're calling out for the one and only Randy Moore. And if your clit is buzzing to the tune of 'Hip Hip Hooray' for a blonde bombshell, it's squirming for some sweet Randy Moore action. This babe's got all the marks of your classic cheerleading mega-whore. She's a knockout chick with golden blonde locks, deep hazel eyes, and a mouth that's sweeter than strawberries dipped in sugar. If you crave seeing a cock penetrate those lips, though, you'll just have to wait because Randy Moore is exclusively a pussy freak, at least for now. Nothing gets her more randy then the wet, salty flavor of gorgeously engorged snatch. If there isn't a lovely lesbo ready and waiting to get eaten out, that's when Randy Moore can't control her masturbatory urges. Whether she's working multiple fingers in her creamy slit, or whipping out some hardcore hardware to vibrate her clit or pump up her cooter, she's always firing on all orgasm cylinders. As for the rest of us, it's impossible not to rub one out while watching Randy do her thing. This Long Beach, Cali girl combines a beautiful face, horny disposition, and a rocking body into one neat wank package. Her incredibly enhanced D-cup tits are the perfect icing on this tasty cake of a lesbian porn star, with nipples sweet enough to leave a cavity in your balls from all the cum she'd cause to seep out.! 041b061a72